ABSTRACT
Vasculitic midline destructive lesions can be a complication of cocaine use. We report a 44-year-old man who presented with a two months history of left facial pain associated with ipsilateral facial paralysis and a cheek phlegmon. Magnetic resonance imaging showed broad soft tissue destruction linked to important cranial nerve involvement. Antibiotic and antifungal therapy was started and multiple surgical debridement procedures were performed, with no clinical improvement. Microbiological analysis was negative. Finally, thanks to the histologic findings corresponding to vasculitis and granuloma formation and the history of cocaine abuse, a cocaine induced midline destructive lesion was diagnosed.
Subject(s)
Humans , Male , Adult , Nose Diseases/diagnosis , Nose Diseases/chemically induced , Cocaine-Related Disorders/complications , Nasal Septum/drug effects , Magnetic Resonance Imaging , Tomography Scanners, X-Ray Computed , Granulomatosis with Polyangiitis/diagnosis , Nose Diseases/therapy , Diagnosis, Differential , Anti-Bacterial Agents/classification , Anti-Bacterial Agents/therapeutic useABSTRACT
Although gastrointestinal symptoms are not rare in Systemic lupus erythematosus, enteritis is an atypical manifestation of the disease. We report a 54 year-old woman who presented acute symptoms of diarrhea, fever and abdominal pain, receiving empiric antibiotic therapy for bacterial enteritis with no response. Computed tomography showed diffuse small intestine inflammation and serositis. Antinuclear antibodies, anti-Ro and anti-La were positive on blood tests. A lupic enteropathy was diagnosed and steroid treatment was initiated, with subsequent clinical improvement.
Subject(s)
Humans , Female , Middle Aged , Enteritis/etiology , Lupus Erythematosus, Systemic/complications , Prednisone/therapeutic use , Tomography, X-Ray Computed , Polymerase Chain Reaction , Treatment Outcome , Enteritis/diagnosis , Enteritis/drug therapy , Glucocorticoids/therapeutic use , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/drug therapyABSTRACT
La ultrasonografía se ha convertido en un examen muy útil para el estudio de artritis inflamatorias indiferenciadas, ya que posee mayor sensibilidad que el examen físico para detectar sinovitis y entesitis. La necesidad de realizar el diagnóstico de forma precoz, ha permitido que esta herramienta se vuelva un pilar fundamental en el enfrentamiento de estas patologías. Se presenta el caso de una paciente de 37 años que consulta por cuadro de seis meses de evolución de poliartralgias de distribución asimétrica en manos, hombros y codos. Al examen físico se detecta sinovitis en articulaciones metacarpofalángicas e interfalángicas proximales. Finalmente se solicita ultrasonografía de manos, la cual revela sinovitis activa en articulaciones interfalángicas distales. En base a esto se rescata antecedente familiar de psoriasis, se realiza HLA-B27 que resulta negativo y un TAC de sacroiliacas sugerente de sacroileítis bilateral. Por los hallazgos y el nuevo antecedente se diagnostica como Artritis Psoriática.
Ultrasonography has become a useful imaging test in the assessment of undifferentiated arthritis, due to its greater sensitivity in detecting synovitis and enthesitis in comparison with physical examination. In the need of making an early diagnosis, this exam has turn into a cornerstone when approaching certain arthritis. We present the case of a 37 years old women, with a six months history of asymmetric polyarthralgias in hands, shoulders and elbows. Synovitis is detected with physical exam in metacarpophalangeal and proximal interphalangeal joints. An ultrasonography is requested, revealing active synovitis in distal interphalangeal joints. Based on these information, the family background of psoriasis is obtained. HLA-B27 results negative and a sacroiliac CT suggests bilateral sacroiliitis. According to these findings the diagnosis of Psoriatic Arthritis is finally made.
Subject(s)
Humans , Adult , Female , Arthritis, Psoriatic , Synovitis , Arthralgia , Early DiagnosisABSTRACT
Abiotrophia defectiva, formerly designated as a member of nutritionally variant streptococci, is part of normal oral flora and may be a cause of culture-negative endocarditis. We report a case of infective endocarditis caused by A. defectiva in a 37-year-old man, allergic to penicillin. We also review the literature for antibiotic treatment alternatives and the microbiological diagnostic possibilities at present.
Abiotrophia defectiva es una cocácea grampositiva considerada anteriormente como parte del grupo de los estreptococos nutricionalmente variables. Es parte de la microbiota oral y puede ser causante de endocarditis bacteriana con cultivo negativo. Se reporta el caso de un paciente varón de 37 años de edad, alérgico a penicilina, con endocarditis infecciosa causada por A. defectiva y se realiza revisión de la literatura sobre las alternativas terapéuticas y el estado actual del diagnóstico microbiológico de este agente.
Subject(s)
Humans , Male , Adult , Endocarditis, Bacterial/microbiology , Gram-Positive Bacterial Infections/microbiology , Streptococcus/isolation & purification , Anti-Bacterial Agents/administration & dosage , Endocarditis, Bacterial/diagnosis , Endocarditis, Bacterial/drug therapy , Gentamicins/administration & dosage , Drug Hypersensitivity/immunology , Microbial Sensitivity Tests , Penicillins/immunology , Vancomycin/administration & dosageABSTRACT
Acute interstitial nephritis is a mononuclear and sterile inflammation of the renal interstice caused by drugs, infections or immune phenomena. The clinical presentation is characterized by the triad of rash, fever and eosinophilia. We report a 32 years old man, in treatment with lamotrigine for depression, admitted to the hospital due to fever, abdominal pain, jaundice, cutaneus rash and malaise. Due to an oliguric renal failure of acute onset, a renal biopsy was done. The pathological study showed a granulomatous acute interstitial nephritis. He was started on hemodialysis and treated with cessation of the drug and corticosteroids, with complete recovery of the renal function (Rev Méd Chile 2004; 132: 742-6).
Subject(s)
Humans , Male , Adult , Antidepressive Agents/adverse effects , Nephritis, Interstitial/chemically induced , Nephritis, Interstitial/pathology , Acute Disease , Kidney/ultrastructureABSTRACT
Hemolytic-uremic syndrome (HUS) is an uncommon complication of pneumococcal infection. Highly suggesting findings in a patient with Streptococcus pneumoniae infection are: microangyopatic hemolytic anemia, thrombocytopenia and acute renal failure. We report a 41 years old woman, admitted to the hospital due to a severe pneumonia, that required the surgical drainage of an empyema. On admission, a drop in packed red cell volume from 41 to 25 percent, the presence of schistocytes in the blood smear, an elevation of LDH to 1,700 IU/L, a fall in haptoglobin to 5.8 mg/dL and a thrombocytopenia of 72,000 per mm3 were detected. These alterations coincided with an oliguric acute renal failure. She was treated with hemodialysis and the hemolytic syndrome was managed with plasmapheresis. She was discharged 35 days after admission and in the follow up, after 2.5 months, her serum creatinine is 1.2 mg/dL and her packed red cell volume is 41 percent